| Cat. No. |
Product Name |
Information |
| PC-38704 |
DF2755A
CXCR1/2 inhibitor
|
DF2755A is a selective, allosteric, orally acting inhibitor of CXCR1/2 (Kd=2.24/0.94 nM), inhibits human PMN (hPMN) migration induced by CXCL8 and CXCL1 with IC50 of 4.2 and 2.1 nM, respectively. |
| PC-38669 |
CXCR7 agonist 1
CXCR7 agonist
|
CXCR agonist 1 is a potent, selective, small molecule agonist of CXCR7 (ACKR3), induces β-arrestin recruitment to CXCR7 and Akt activation, inhibits CXCL12-induced tube formation in HUVECs with EC50 of 0.96 nM. |
| PC-38499 |
Cenicriviroc
CCR2/CCR5 inhibitor
|
Cenicriviroc (TAK-652, TBR-652) is a potent, selective, orally active, dual CCR2/CCR5 antagonist with IC50 of 5.9/0.29 nM, inhibits both HIV-1 and HIV-2 and prevents viral cellular entry. |
| PC-38487 |
VUF11418
CXCR3 agonist
|
VUF11418 is a selective, nonpeptidomimetic agonist of CXCR3 with binding pKi vaule of 7.2, pEC50 value of 6.0 in [35S]GTPγS functional assays. |
| PC-38366 |
Lazucirnon
CCR3 antagonist
|
Lazucirnon (KST4290, ALK4290) is a small molecule, orally active inhibitor against CCR3, the natural receptor for chemokine eotaxin, decreases inflammatory cytokines in preclinical models. |
| PC-73268 |
NBI-74330
CXCR3 antagonist
|
NBI-74330 is a potent, selective CXC chemokine receptor 3 (CXCR3) antagonist, inhibits [(125)I]CXCL10 and [(125)I]CXCL11 specific binding with Ki of 1.5 and 2.3 nM, respectively. |
| PC-73267 |
AMD3451
CXCR5/CXCR4 antagonist
|
AMD3451 is a specific, dual CXCR5/CXCR4 antagonist with antiviral activity against a wide variety of HIV-1 and HIV-2 (IC50=1.2 to 26.5 uM) in vitro. |
| PC-73266 |
AstraZeneca CCR4 antagonist
CCR4 antagonist
|
AstraZeneca CCR4 antagonist is a potent, selective CCR4 antagonist, inhibits CCR4 ligand macrophage-derived chemokine (MDC/CCL22) in CCR4+CD4+ T cells. |
| PC-73265 |
RS-1748
CCR4 antagonist
|
RS-1748 is a highly potent, selective, orallu active CCR4 antagonist, inhibits [125I]CCL17 binding to human CCR4 with IC50 of 27.7 nM. |
| PC-73264 |
RS-1269
CCR4 antagonist
|
RS-1269 is a highly potent, selective CCR4 antagonist, inhibits [125I]CCL17 binding to human CCR4 with IC50 of 27.7 nM. |
| PC-73263 |
CCR4-IN-22
CCR4 antagonist
|
CCR4-IN-22 (Compound 22) is a potent, selective CCR4 antagonist with IC50 of 20 nM, efficiently inhibits CCR4-mediated Ca2+ mobilization and chemotaxis in vitro with IC50 of 3 and 7 nM, repectively. |
| PC-73262 |
GSK2239633A
CCR4 antagonist
|
GSK2239633A is a potent, allosteric CC-chemokine receptor 4 (CCR4) antagonist with pIC50 of 7.83 in 35S-GTPγS competition assay. |
