ACT-660602 | CXCR3 antagonist | Probechem Biochemicals

Chemical Structure : ACT-660602

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ACT-660602 (ACT660602)

货号: PC-49265Not For Human Use, Lab Use Only.

ACT-660602 (ACT660602) is a potent, selective and orally bioavailable CXCR3 antagonist with IC50 of 204 nM in human blood.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ACT-660602 (ACT660602) is a potent, selective and orally bioavailable CXCR3 antagonist with IC50 of 204 nM in human blood.
ACT-660602 displays high biological potency in inhibiting cell migration together with improvements of the metabolic stability and hERG issue.
ACT-660602 (30 mg/kg, q.d. po) significantly reduced recruitment of the CXCR3+ CD8+ T cell in the bronchoalveolar lavage compartment in LPS-induced lung inflammation model in mice.

物理化学性质&存储条件

分子量	534.485
分子式	C20H20F6N8OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-1-(2-methyl-4-(2-(trifluoromethyl)-4-(2-(trifluoromethyl)pyrimidin-5-yl)thiazol-5-yl)piperazin-1-yl)ethan-1-one

参考文献

1. Emmanuel A Meyer, et al. J Med Chem. 2022 Aug 10. doi: 10.1021/acs.jmedchem.2c00675.

ACT-660602 (ACT660602)

生物&药学活性

物理化学性质&存储条件

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ACT-660602 (ACT660602)

生物&药学活性

物理化学性质&存储条件

参考文献

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