| Cat. No. |
Product Name |
Information |
| PC-22931 |
LN5972
ACKR3 agonist
|
LN5972 (LN-5972) is a potent, selective and first-in-class agonist of the atypical chemokine receptor 3 (ACKR3, CXCR7) with β-arrestin EC50 of 3.4 uM. |
| PC-22930 |
ACKR3 agonist 27
ACKR3 agonist
|
ACKR3 agonist 27 is a potent, selective small molecule agonist of atypical chemokine receptor ACKR3 (CXCR7) with EC50 of 69 nM in β-arrestin recruitment assays, Emax=82%. |
| PC-22322 |
IDOR-1117-2520
CCR6 inhibitor
|
IDOR-1117-2520 is a potent, selective CCR6 antagonist with IC50 of 62.9 nM for CCL20-mediated calcium flow inhibition in FLIPR calcium mobilization assay. |
| PC-21897 |
Maraviroc
CCR5 antagonist
|
Maraviroc (UK-427857) is a potent, selective and orally bioavailable CCR5 inhibitor with IC50 of 3.3 nM, 7.2 nM and 5.2 nM for MIP-1α, MIP-1β and RANTES binding to cell membrane preparations of CCR5-expressing HEK-293, shows broad-spectrum activity against HIV-1. |
| PC-21816 |
VUF11222
CXCR3 agonist
|
VUF11222 is a potent, selective and nonpeptidomimetic CXCR3 agonist with binding pKi of 7.2, and pEC50 of 6.1 in [35S]GTPγS functional assays. |
| PC-21785 |
VUF15485
ACKR3 agonist
|
VUF15485 is a small-molecule agonist of the atypical chemokine receptor ACKR3 with binding pIC50 of 8.3, and pEC50 of 7.6 in BRET-based β-arrestin2 recruitment assay. |
| PC-21292 |
GPC-100 hydrobromide
CXCR4 antagonist
|
GPC-100 (TG-0054, Burixafor) is a novel small molecule antagonist of CXCR4, shows competitive inhibition of CXCL12 binding to CXCR4 with Ki of 1.6 nM. |
| PC-21104 |
DAPTA
CCR5 antagonist
|
DAPTA (D-ala-peptide T-amide, Adaptavir) is an HIV gp120-derived CCR5 entry inhibitor, inhibits CCR5-mediated monocyte migration and attenuates neuroinflammation. |
| PC-21102 |
RAP-103
CCR2 antagonist
|
RAP-103 is an orally active, stabilized pentapeptide analog of DAPTA (D-ala-peptide T-amide), and multi-chemokine receptor antagonist. |
| PC-21101 |
UCUF-965
CXCR4 modulator
|
UCUF-965 (UCUF965) is a potent partial agonist and positive allosteric modulator of CXCR4 with EC50 of 0.02 uM, Emax=44% for CXCR4/CXCL12 signaling for β-arrestin-2 recruitment. |
| PC-21011 |
KAND567
CX3CR1 inhibitor
|
KAND567 (AZD8797) is a potent, selective and orally available C-X3-C motif chemokine receptor 1 (CX3CR1, fractalkine receptor) antagonist with binding Ki of 3.9 nM (human CX3CR1), 720-fold selectivity over CXCR2. |
| PC-20761 |
PF-07054894
CCR6 inhibitor
|
PF-07054894 is a potent, functionally selective CCR6 antagonist, blocks in vitro CCL20- dependent human T cell chemotaxis with IC50 of 5.7 nM. |
