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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-RS102895
RS102895

Chemical Structure : RS102895

CAS No.: 300815-41-2

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RS102895 (Abaucin, RS102895)

货号: PC-45483Not For Human Use, Lab Use Only.

RS-102895 (Abaucin, RS102895) is a potent and specific CCR2 antagonist with binding IC50 of 360 nM, also is a narrow-spectrum activity against A. baumannii.

规格 价格 库存 数量
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RS-102895 (Abaucin, RS102895) is a potent and specific CCR2 antagonist with binding IC50 of 360 nM, also is a narrow-spectrum activity against A. baumannii.
RS-102895 shows no significant affinity on CXCR1, CCR1, or CCR3 (IC50>17 uM).
RS-102895 inhibits MCP-1-stimulated calcium influx into CCR2-CHL cells with IC50 of 32 nM.
RS-102895 significantly attenuates HG-induced ECM protein expression and TGF-beta1 levels in mouse mesangial cells (MCs).
RS-102895 (Abaucin, RS102895) is an antibacterial compound with narrow-spectrum activity against A. baumannii, perturbs lipoprotein trafficking through a mechanism involving LolE.

物理化学性质&存储条件

分子量 390.3989
分子式 C21H21F3N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-

参考文献

1. Mirzadegan T, et al. J Biol Chem. 2000 Aug 18;275(33):25562-71.
2. Park J, et al. Am J Physiol Renal Physiol. 2008 Sep;295(3):F749-57.
3. Hung YW, et al. J Neuroinflammation. 2013 Jan 22;10:11.
4. Gary Liu, et al. Nat Chem Biol. 2023 May 25. doi: 10.1038/s41589-023-01349-8.

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