| Cat. No. |
Product Name |
Information |
| PC-61289 |
POL5551
CXCR4 inhibitor
|
POL5551 is a peptidic, potent and highly selective CXCR4 antagonist with IC50 of 1.7 nM. |
| PC-61173 |
NVP-BDZ 824
CXCR3 inhibitor
|
NVP-BDZ 824 is a potent, highly selective antagonist of chemokine receptor CXCR3 with binding IC50 of 146 nM, Ca2+-mobilization IC50 of 28 nM. |
| PC-61172 |
RAMX3
CXCR3 modulator
|
RAMX3 is a tritium-labeled allosteric modulator of the human chemokine receptor CXCR3 with Kd of 1.08 nM. |
| PC-61171 |
FAUC 1104
CXCR3 agonist
|
FAUC 1104 is a potent, biased allosteric agonist of CXCR3 (pEC50=5.22) that activates solely G proteins, induces chemotaxis, but fails to induce receptor internalization or β-arrestin 2 recruitment. |
| PC-61170 |
FAUC 1036
CXCR3 agonist
|
FAUC 1036 is a potent, biased allosteric agonist of CXCR3 (pEC50=6.64), selectively induces chemotaxis and receptor internalization, and induces β-arrestin 2 recruitment without any stimulation of G proteins. |
| PC-61090 |
GSK 163929
CCR5 antagonist
|
GSK 163929 is a potent, selective CCR5 antagonist and HIV-1 entry inhibitor with pIC50 of 8.37 and 8.46 in HOS and PBL assays, respectively. |
| PC-61089 |
GSK 214096
CCR5 antagonist
|
GSK 214096 potent, selective CCR5 antagonist and HIV-1 entry inhibitor, inhibits HIV-1 glycoprotein 120 (gp120) binds to the CD4+ T-cell receptor. |
| PC-60972 |
LMD-009
CCR8 agonist
|
LMD-009 (LMD 009, LMD009) is a potent, selective, nonpeptide CCR8 agonist that stimulates CCR8-mediated chemotaxis, inositol phosphate accumulation and calcium release with EC50 of 11-87 nM. |
| PC-60855 |
LMD-A
CCR8 antagonist
|
LMD-A (CCR8 antagonist LMD-A) is a highly potent, small molecule antagonist of chemokine receptor CCR8 with EC50 of 2.5 nM. |
| PC-60779 |
E 6130
CX3CR1 inhibitor
|
E6130 is a potent, selective, orally available CX3C chemokine receptor 1 (CX3CR1) modulator that inhibits the fractalkine-induced chemotaxis of human peripheral blood NK cells with IC50 of 4.9 nM. |
| PC-60672 |
INCB9471
CCR5 antagonist
|
INCB9471 is a potent, selective and orally bioavailable CCR5 antagonist IC50 of 6.5 nM, Kd of 3.1 nM in human PBMCs. |
| PC-60626 |
CX797
CXCR2 antagonist
|
CX797 is a potent, specfic CXCR2 antagonist that inhibits IL8 down-regulation of forskolin-induced cAMP with IC50 of 7.79 uM. |
