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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-POL5551
POL5551

Chemical Structure : POL5551

CAS No.: 1569304-29-5

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POL5551 (POL-5551;POL 5551)

货号: PC-61289Not For Human Use, Lab Use Only.

POL5551 is a peptidic, potent and highly selective CXCR4 antagonist with IC50 of 1.7 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

POL5551 is a peptidic, potent and highly selective CXCR4 antagonist with IC50 of 1.7 nM.
POL5551 displays about 200-fold lower than Plerixafor (IC50=400-600 nM), and mobilizes hematopoietic stem and progenitor cells (HSPCs) with greater efficiency than Plerixafor, does not induce major morphological changes in the BM of mice.
POL5551 reduces the migration of breast cancer cells in vitro, and reduces metastasis and prolongs survival in mice.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Karpova D, et al. Leukemia. 2013 Dec;27(12):2322-31.

2. Xiang J, et al. Mol Cancer Ther. 2015 Nov;14(11):2473-85.

3. Sison EA, et al. Oncotarget. 2015 Oct 13;6(31):30902-18.

4. DeMarco SJ, et al. Bioorg Med Chem. 2006 Dec 15;14(24):8396-404.

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