AZD8309 | CXCR2 antagonist | Probechem Biochemicals

Chemical Structure : AZD8309

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AZD8309 (AZD-8309)

货号: PC-61471Not For Human Use, Lab Use Only.

AZD8309 is a potent and orally bioavailable CXCR2 antagonist that has been proposed to regulate the transmigration of neutrophils.

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生物&药学活性

AZD8309 is a potent and orally bioavailable CXCR2 antagonist that has been proposed to regulate the transmigration of neutrophils.
AZD8309 significantly reduces MPO in the pancreas and lungs, and reduces intrapancreatic trypsin and elastase activity in caerulein-pancreatitis.
AZD8309 also reduces cathepsin B activity and MPO in taurocholate-pancreatitis; also antagonises the CCR2b receptor but it is 10-fold less potent than at CXCR2.

物理化学性质&存储条件

分子量	384.42
分子式	C15H14F2N4O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-((2,3-difluorobenzyl)thio)-7-((1-hydroxypropan-2-yl)amino)thiazolo[4,5-d]pyrimidin-2(3H)-one

参考文献

1. Virtala R, et al. Clin Exp Allergy. 2012 Apr;42(4):590-6.

2. Leaker BR, et al. Respir Res. 2013 Dec 16;14:137.

3. Malla SR, et al. Pancreatology. 2016 Sep-Oct;16(5):761-9.

AZD8309 (AZD-8309)

生物&药学活性

物理化学性质&存储条件

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AZD8309 (AZD-8309)

生物&药学活性

物理化学性质&存储条件

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