| Cat. No. |
Product Name |
Information |
| PC-61968 |
Aplaviroc
CCR5 antagonist
|
Aplaviroc (GSK-873140, GW 873140, AK-602, ONO-4128) is a potent, noncompetitive, allosteric antagonist of the CCR5 receptor with pKb of 8.6. |
| PC-61967 |
CP-481715
CCR1 inhibitor
|
CP-481715 is a potent and selective CCR1 antagonist with Ki of 9.2 nM and IC50 of 74 nM, lacks intrinsic agonist activity. |
| PC-61966 |
MLN 3897
CCR1 inhibitor
|
MLN 3897 is a potent, specific and orally active antagonist of CCR1 with IC50 of 0.8 nM in competition binding assays, 500-fold selectivity over CCR5. |
| PC-61965 |
FC131
CXCR4 antagonist
|
FC131 (cyclo(-D-Tyr-Arg-Arg-Nal-Gly-)) is a selective, cyclopentapeptide CXCR4 antagonist with IC50 of 126 nM, exhibits anti-HIV activity in assays using NL4-3 and IIIB strains with EC50 of 21 nM.. |
| PC-61964 |
CMPD167
CCR5 antagonist
|
CMPD167 (MRK-1) is an orally acitve small molecule that binds to CCR5 to inhibit gp120 association, inhibits different stages of the virus-cell attachment and entry process (CCR5-using virus SHIV-162P3, IC50<1 nM). |
| PC-61688 |
AZD 1678
CCR4 antagonist
|
AZD 1678 is a potent, selective orally bioavailable CCR4 receptor antagonist with pIC50 of 8.6 for hCCR4, pIC50 of 9.0 for rCCR4. |
| PC-61687 |
AZD2098
CCR4 antagonist
|
AZD2098 (AZD-2098) is a potent, selective, orally bioavailable CCR4 receptor antagonist with pIC50 of 7.8 for hCCR4, pIC50 of 8.0 for rCCR4. |
| PC-61582 |
PF-232798
CCR5 antagonist
|
PF-232798 (PF-00232798) is a potent CCR5 antagonist with IC50 of <0.1 nM in gp160 fusion assay, exhibits potent broad-spectrum anti-HIV-1 activity. |
| PC-61576 |
INCB10820
Dual CCR2/5 antagonist
|
INCB10820 (PF-4178903) is a potent, selective, orally bioavailable dual CCR2 and CCR5 antagonist with binding IC50 of 3.0 nM and 5.3 nM, respectively. |
| PC-61558 |
PF-04634817
CCR2/5 antagonist
|
PF-04634817 is a potent, orally bioavailble CCR2 and CCR5 chemokine receptor antagonist for the treatment of diabetic nephropathies and diabetic macular oedema. . |
| PC-61557 |
PF-04136309
CCR2 antagonist
|
PF-4136309 (INCB8761) is a potent, selective, competitive, reversible full CCR2 antagonist with IC50 of 2-5 nM. |
| PC-61474 |
Ladarixin
CXCR1/CXCR2 inhibitor
|
Ladarixin (DF 2156) is an allosteric, noncompetitive dual CXCR1/2 inhibitor that inhibits human polymorphonuclear leukocyte (PMN) migration to CXCL8 in vitro with IC50 of 0.7 nM. |
