R243 |CAS:688352-84-3 Probechem Biochemicals

Chemical Structure : R243

CAS No.: 688352-84-3

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R243 (R-243;R 243)

货号: PC-63440Not For Human Use, Lab Use Only.

R243 is a potent, small molecule CCR8 antagonist that inhibits CCR8 signaling and chemotaxis, inhibits CCL1-induced Ca2+ flux and CCL1-driven peritoneal macrophages aggregation at 0.2 uM.

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10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4580	In stock
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生物&药学活性

R243 is a potent, small molecule CCR8 antagonist that inhibits CCR8 signaling and chemotaxis, inhibits CCL1-induced Ca2+ flux and CCL1-driven peritoneal macrophages aggregation at 0.2 uM.
R243 attenuated secretion of TNF-α, IL-6, and most strikingly IL-10 from WT PMφ (peritoneal macrophages), but not BMMφ (bone marrow-derived macrophages).
R243 shows suppressed c-JNK activity and NF-κB signaling after LPS treatment, suppresses LPS-induced cytokine secretion; attenuates peritoneal adhesions in vivo in CCR8-/- mice, also prevents hapten-induced colitis.

物理化学性质&存储条件

分子量	357.45
分子式	C21H27NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	7,8-Dihydro-7-[2-(tricyclo[3.3.1.1(3,7)]dec-1-yloxy)ethyl]-6H-1,3-dioxolo[4,5-g][1,3]benzoxazine

参考文献

1. Oshio T, et al. PLoS One. 2014 Apr 8;9(4):e94445.

2. Berenguer J, et al. J Extracell Vesicles. 2018 Mar 13;7(1):1446660.

R243 (R-243;R 243)

生物&药学活性

物理化学性质&存储条件

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R243 (R-243;R 243)

生物&药学活性

物理化学性质&存储条件

参考文献

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