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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-TIQ-15
TIQ-15

Chemical Structure : TIQ-15

CAS No.: 1380336-17-3

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TIQ-15 (TIQ15)

货号: PC-35087Not For Human Use, Lab Use Only.

TIQ-15 is a potent and selective CXCR4 antagonist, inhibits attachment of X4 HIV-1IIIB virus in MAGI-CCR5/CXCR4 cells with IC50 of 3 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    TIQ-15 is a potent and selective CXCR4 antagonist, inhibits attachment of X4 HIV-1IIIB virus in MAGI-CCR5/CXCR4 cells with IC50 of 3 nM.
    TIQ-15 inhibits calcium release in Chem-1 cells with IC50 of 3 nM.
    TIQ-15 shows no cross-activity in a panel of chemokine receptor assays in both CXCR and CCR types.

    物理化学性质&存储条件

    分子量 364.537
    分子式 C23H32N4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N1-(((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)-N1-((S)-5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine

    参考文献

    1. Truax VM, et al. ACS Med Chem Lett. 2013 Sep 5;4(11):1025-30.

    2. Yesim A. Tahirovic, et al. ACS Med. Chem. Lett., 2018, 9 (5), pp 446-451.

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