CCR10 antagonist 1 |CAS:1191031-97-6 Probechem Biochemicals

Chemical Structure : CCR10 antagonist 1

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CCR10 antagonist 1

货号: PC-35029Not For Human Use, Lab Use Only.

CCR10 antagonist 1 is a potent, selective CCR10 antagonist with IC50 of 690 nM.

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1 g		Get quote

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生物&药学活性

CCR10 antagonist 1 is a potent, selective CCR10 antagonist with IC50 of 690 nM.
CCR10 antagonist 1 demonstrates functional CCR1 antagonism by inhibiting the CCL27 dependent chemotaxis of Ba/F3 cells stably transfected with human CCR10 with an IC50 of 53 nM.
CCR10 antagonist 1 exhibits no antagonism of murine CCL27 dependent Ca2+ flux in CHO-K cells stably transfected with murine CCR10 at 20 uM.

物理化学性质&存储条件

分子量	519.398
分子式	C19H24Cl2N6O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-amino-3,5-dichloro-N-(1-(4-methylpiperidin-1-yl)-4-(2-nitro-1H-imidazol-1-yl)-1-oxobutan-2-yl)benzenesulfonamide

参考文献

1. Abeywardane A, et al. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5277-5283.