BMS-817399 |CAS:1202400-18-7 Probechem Biochemicals

Chemical Structure : BMS-817399

CAS No.: 1202400-18-7

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BMS-817399 (BMS817399)

货号: PC-35036Not For Human Use, Lab Use Only.

BMS-817399 is a potent, selective, orally bioavailable CCR1 antagonist with binding IC50 of 1 nM, inhibits MIP-1α-induced chemotaxis with IC50 of 6 nM.

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10 mg	￥4880	In stock
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生物&药学活性

BMS-817399 is a potent, selective, orally bioavailable CCR1 antagonist with binding IC50 of 1 nM, inhibits MIP-1α-induced chemotaxis with IC50 of 6 nM.
BMS-817399 shows no binding activity to other CC family receptors, including CCR2, CCR3, CCR4, CCR5, CXCR2, CXCR3, and CXCR5, as well as a broad panel of other GPCRs and biogenic amine transporters.
BMS-817399 blocks MIP1α- and LKN-1-mediated up-regulation of CD11b in human whole blood with IC50 values of 25 nM and 42 nM, respectively.
BMS-817399 shows potential for the treatment of rheumatoid arthritis.

物理化学性质&存储条件

分子量	454.008
分子式	C23H36ClN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-3-(2-hydroxy-2-methylpropyl)urea

参考文献

1. Santella JB 3rd, et al. J Med Chem. 2014 Sep 25;57(18):7550-64.

BMS-817399 (BMS817399)

生物&药学活性

物理化学性质&存储条件

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BMS-817399 (BMS817399)

生物&药学活性

物理化学性质&存储条件

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