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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-BX471 hydrochloride
BX471 hydrochloride

Chemical Structure : BX471 hydrochloride

CAS No.: 288262-96-4

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BX471 hydrochloride (BX-471 hydrochloride, BX 471 hydrochloride)

货号: PC-42890Not For Human Use, Lab Use Only.

BX471 is a potent, selective, orally available CCR1 antagonist with Ki of 1 nM for hCCR1, displays 100 times less affinity for rat CCR1.

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10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BX471 hydrochloride is a potent, selective, orally available CCR1 antagonist with Ki of 1 nM for hCCR1, displays 100 times less affinity for rat CCR1.
BX471 shows 10,000-fold selectivity for CCR1 compared with 28 GPCRs.
BX471 displays CCR1 ligands MIP-1α, RANTES, and MCP-3 with high affinity (Ki=1-5.5 nM), inhibits a number of CCR1-mediated effects including Ca(2+) mobilization, increase in extracellular acidification rate, CD11b expression.
BX471 effectively reduces disease in a rat experimental allergic encephalomyelitis model of multiple sclerosis.

物理化学性质&存储条件

分子量 471.3526
分子式 C21H25Cl2FN4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-, hydrochloride (1:1)

参考文献

1. Horuk R, et al. J Biol Chem. 2001 Feb 9;276(6):4199-204.

2. Anders HJ, et al. J Clin Invest. 2002 Jan;109(2):251-9.

3. Strasly M, et al. Blood. 2004 Jan 1;103(1):40-9.

4. Liang M, et al. J Biol Chem. 2000 Jun 23;275(25):19000-8.

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