GSK812397 |CAS:878197-98-9 Probechem Biochemicals

Chemical Structure : GSK812397

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GSK812397 (GSK 812397;GSK-812397)

货号: PC-35088Not For Human Use, Lab Use Only.

GSK812397 is a potent, selective, noncompetitive, orally available antagonist of CXCR4 receptor, inhibits entry of X4-tropic strains of HIV-1 with IC50 of 4.60 nM and 1.50 nM in PBMCs and HOS assays, respectively.

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生物&药学活性

GSK812397 is a potent, selective, noncompetitive, orally available antagonist of CXCR4 receptor, inhibits entry of X4-tropic strains of HIV-1 with IC50 of 4.60 nM and 1.50 nM in PBMCs and HOS assays, respectively.
GSK812397 does not block CCR5-mediated viral entry in the R5 viral HOS assay (IC50>25 uM).
GSK812397 produces a concentration-dependent decrease in both an SDF-1-mediated chemotaxis and intracellular calcium release (IC50=0.34 nM and 2.41 nM, respectively) in cell-based functional assays.
GSK812397 demonstrates antiviral activity against a broad range of X4-utilizing strains of HIV-1.

物理化学性质&存储条件

分子量	420.561
分子式	C24H32N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-(2-((methyl(5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)-5-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyridin-3-yl)methanol

参考文献

1. Jenkinson S, et al. Antimicrob Agents Chemother. 2010 Feb;54(2):817-24.

GSK812397 (GSK 812397;GSK-812397)

生物&药学活性

物理化学性质&存储条件

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GSK812397 (GSK 812397;GSK-812397)

生物&药学活性

物理化学性质&存储条件

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