| Cat. No. |
Product Name |
Information |
| PC-35358 |
BL5923
CCR1 inhibitor
|
BL5923 (BL-5923) is a potent, highly specific, orally available inhibitor of CCR1 with IC50 of 20.4 and 22.8 nM for human and mouse CCR1, resepctively. |
| PC-35323 |
JMS-17-2
CX3CR1 inhibitor
|
JMS-17-2 is a potent and selective antagonist of CX3CR1 with IC50 of 0.32 nM, displays significant selectivity for CX3CR1 over other chemokine receptors such CXCR2, CXCR1, and CXCR4 (IC50>1 uM). |
| PC-35226 |
GW 766994
CCR3 antagonist
|
GW 766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays. |
| PC-35220 |
MLN3126
CCR9 antagonist
|
MLN3126 (MLN 3126, MLN-3126) is a potent, selective, orally available CCR9 antagonist with IC50 of 6.3 nM (CCL25-induced calcium mobilization). |
| PC-35088 |
GSK812397
CXCR4 antagonist
|
GSK812397 is a potent, selective, noncompetitive, orally available antagonist of CXCR4 receptor, inhibits entry of X4-tropic strains of HIV-1 with IC50 of 4.60 nM and 1.50 nM in PBMCs and HOS assays, respectively. |
| PC-35087 |
TIQ-15
CXCR4 antagonist
|
TIQ-15 is a potent and selective CXCR4 antagonist, inhibits attachment of X4 HIV-1IIIB virus in MAGI-CCR5/CXCR4 cells with IC50 of 3 nM. |
| PC-35039 |
BI 639667
CCR1 inhibitor
|
BI 639667 (BI639667) is a potent and selective antagonist of human CCR1 with binding IC50 of 5.4 nM, inhibits chemotaxis with IC50 of 2.4 nM. |
| PC-35036 |
BMS-817399
CCR1 inhibitor
|
BMS-817399 is a potent, selective, orally bioavailable CCR1 antagonist with binding IC50 of 1 nM, inhibits MIP-1α-induced chemotaxis with IC50 of 6 nM. |
| PC-35030 |
BI 6901
CCR10 antagonist
|
BI 6901 is a potent, selective CCR10 antagonist with Aequorin Ca2+ flux pIC50 of 9.0, shows high selectivity over other GPCRs. |
| PC-35029 |
CCR10 antagonist 1
|
CCR10 antagonist 1 is a potent, selective CCR10 antagonist with IC50 of 690 nM. |
| PC-63566 |
BMS-457
CCR1 inhibitor
|
BMS-457 is a potent and selective CCR1 antagonist with binding IC50 of 0.8 nM, >1,000-fold selectivity against other CC family receptors. |
| PC-63440 |
R243
|
R243 is a potent, small molecule CCR8 antagonist that inhibits CCR8 signaling and chemotaxis, inhibits CCL1-induced Ca2+ flux and CCL1-driven peritoneal macrophages aggregation at 0.2 uM. |
