HF50731 | CXCR4 antagonist | Probechem Biochemicals

Chemical Structure : HF50731

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HF50731 (HF-50731)

货号: PC-72032Not For Human Use, Lab Use Only.

HF50731 (HF-50731) is a novel potent, selective CXCR4 antagonist with Ki of 19.8 nM in the CXCR4 competitive binding assay.

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生物&药学活性

HF50731 (HF-50731) is a novel potent, selective CXCR4 antagonist with Ki of 19.8 nM in the CXCR4 competitive binding assay.
HF50731 significantly inhibited SDF-1α-induced calcium mobilization (IC50=621 nM) and cell migration, and blocked HIV-1 infection via antagonizing CXCR4 coreceptor function (IC50=1.5 uM).
The structure-activity relationship analysis demonstrated that HF50731 could primarily occupy the minor subpocket of CXCR4 and partially bind in the major subpocket by interacting with residues W94, D97, D171, and E288.

物理化学性质&存储条件

分子量	414.682
分子式	C26H46N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1,N1'-(1,4-phenylenebis(methylene))bis(N3-cyclohexylpropane-1,3-diamine)

参考文献

1. Xiong Fang, et al. Eur J Med Chem. 2020 Aug 15;200:112410.

HF50731 (HF-50731)

生物&药学活性

物理化学性质&存储条件

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HF50731 (HF-50731)

生物&药学活性

物理化学性质&存储条件

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