CXCR7 modulator 18

Chemical Structure : CXCR7 modulator 18

CAS No.: 2227426-37-9

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货号: PC-72636Not For Human Use, Lab Use Only.

CXCR7 modulator 18 is a novel potent, selective CXCR7 modulator with Ki of 13 nM, β-arrestin EC50 of 11 nM.

规格	价格	库存
2 mg	￥2980	In stock
5 mg	￥4980	In stock
10 mg	￥7980	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

CXCR7 modulator 18 is a novel potent, selective CXCR7 modulator with Ki of 13 nM, β-arrestin EC50 of 11 nM.
CXCR7 modulator 18 demonstrates excellent selectivity profile adrenergic α1a Kb >10 ,000 nM, and adrenergic β2 Kb, CXCR4 Ki >1 uM.
Administration of CXCR7 modulator 18 in mice led to a statistically significant increase in circulating concentrations of plasma stromal-cell-derived factor 1α (SDF-1α) of approximately 2-fold.
Chronic dosing of compound 18 in a mouse model of isoproterenol-induced cardiac injury further resulted in a statistically significant reduction of cardiac fibrosis.

物理化学性质&存储条件

分子量	522.694
分子式	C29H42N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(βS)-4-(7-Ethylimidazo[1,2-a]pyridin-8-yl)hexahydro-β-[1-[(1R,2S,4S)-7-oxabicyclo[2.2.1]hept-2-ylcarbonyl]-4-piperidinyl]-1H-1,4-diazepine-1-propanamide

参考文献

1. Elnaz Menhaji-Klotz, et al. J. Med. Chem. 2018, 61, 8, 3685–3696