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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-CCR4-IN-31
CCR4-IN-31

Chemical Structure : CCR4-IN-31

CAS No.: 2206788-99-8

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CCR4-IN-31

货号: PC-73030Not For Human Use, Lab Use Only.

CCR4-IN-31 is a potent, selective, orally bioavailable CCR4 antagonist with IC50 of 40 nM (Ca2+ flux).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CCR4-IN-31 is a potent, selective, orally bioavailable CCR4 antagonist with IC50 of 40 nM (Ca2+ flux).
    CCR4-IN-31 exhibited high potency in distinct functional assays in addition to good in vitro and in vivo ADME properties.
    CCR4-IN-31 potentiate antitumor immune responses.

    物理化学性质&存储条件

    分子量 511.451
    分子式 C26H28Cl2N6O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-((R)-1-(2,4-dichlorophenyl)ethyl)-6-((4S,5R)-4-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-5-methylcyclohex-1-en-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile

    参考文献

    1. Jackson JJ, et al. J Med Chem. 2019 Jul 11;62(13):6190-6213.

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