CCR4-351 | CCR4 antagonist | Probechem Biochemicals

Chemical Structure : CCR4-351

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CCR4-351 (CCR4-IN-38)

货号: PC-73031Not For Human Use, Lab Use Only.

CCR4-IN-38 (CCR4-351) is a potent, selective, orally bioavailable CCR4 antagonist with IC50 of 50 nM (Chemotaxis inhibition).

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生物&药学活性

CCR4-IN-38 (CCR4-351) is a potent, selective, orally bioavailable CCR4 antagonist with IC50 of 50 nM (Chemotaxis inhibition).
CCR4-IN-38 inhibits the recruitment of Treg into the tumor microenvironment (TME).
CCR4-IN-38 elicits antitumor responses as a single agent or in combination with an immune checkpoint blockade.

物理化学性质&存储条件

分子量	500.428
分子式	C24H27Cl2N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((R)-1-(2,4-dichlorophenyl)ethyl)-6-(3-((R)-1-(2-hydroxyethyl)piperidin-3-yl)azetidin-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile

参考文献

1. Omar Robles, et al. J Med Chem. 2020 Aug 13;63(15):8584-8607.

CCR4-351 (CCR4-IN-38)

生物&药学活性

物理化学性质&存储条件

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CCR4-351 (CCR4-IN-38)

生物&药学活性

物理化学性质&存储条件

参考文献

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