| Cat. No. |
Product Name |
Information |
| PC-49464 |
RPT193
CCR4 inhibitor
|
RPT193 (RPT-193) is a highly potent, selective and orally active CCR4 antagonist, inhibits CCL22- induces human Th2 chemotaxis with IC50 of 370 nM. |
| PC-49368 |
LN6023
ACKR3 agonist
|
LN6023 (LN-6023) is a potent, selective and first-in-class agonist of the atypical chemokine receptor 3 (ACKR3, CXCR7) with β-arrestin EC50 of 3.5 uM. |
| PC-49306 |
MR120
CCR6 inhibitor
|
MR120 (CCR6 antagonist 1b) is a potent, selective CCR6 antagonist, disrupts the CCL20-induced chemotaxis of CCR6+CD4+ T cells. |
| PC-49265 |
ACT-660602
CXCR3 antagonist
|
ACT-660602 (ACT660602) is a potent, selective and orally bioavailable CXCR3 antagonist with IC50 of 204 nM in human blood. |
| PC-49264 |
ACT-672125
CXCR3 antagonist
|
ACT-672125 (ACT672125) is a potent, selective CXCR3 antagonist with IC50 of 239 nM in human blood. |
| PC-49202 |
AMD3465
CXCR4 antagonist
|
AMD3465 (AMD 3465) is a potent, selective monomacrocyclic CXCR4 antagonist with IC50 of 0.75 nM for inhibition of 12G5 mAb binding to CXCR4, dose-dependently inhibits CXCL12 binding in SupT1 cells with IC50 of 18 nM. |
| PC-49201 |
BPRCX714
CXCR4 antagonist
|
BPRCX714 (BPRCX 714) is a highly selective and potent CXCR4 antagonist with binding IC50 of 34.2 nM, effectively inhibits CXCL12-induced movement of CCRF-CEM cells with EC50 of 13.7 nM. |
| PC-49200 |
BPRCX807
CXCR4 antagonist
|
BPRCX807 (BPRCX-807) is a highly selective and potent CXCR4 antagonist with binding IC50 of 40.4 nM and EC50 of 48.1 nM for cell-mobility activity in the chemotaxis assays, inhibits CXCL12-mediated cell signaling pathway. |
| PC-49142 |
BMS-753426
CCR2 inhibitor
|
BMS-753426 is a potent, selective and orally bioavailable antagonist of CCR2 with binding IC50 of 2.7 nM, 30-fold selectivity over CCR5. |
| PC-38757 |
CCR9 inhibitor 12
CCR9 inhibitor
|
CCR9 inhibitor 12 is a potent inhibitor of chemokine receptor 9 (CCR9) with IC50 of 20 nM in calcium (Ca2+) FLIPR assay, shows IC50 of 277 nM in chemotaxis assays. |
| PC-38725 |
WZ811
CXCR4 inhibitor
|
WZ811 is a nonpeptidic, small molecule antagonist of CXCR4 with EC50 of 0.3 nM affinity binding assays, suppresses cancer cells aggressive in a variety of cancers. |
| PC-38724 |
MSX-122
CXCR4 inhibitor
|
MSX-122 is a small molecule and partial CXCR4 antagonist, directly binds to the CXCL12 site on CXCR4 and inhibits CXCR4/CXCL12 actions with IC50 of 10 nM. |
