NUCC-390 | CXCR4 agonist | Probechem Biochemicals

Chemical Structure : NUCC-390

CAS No.: 1060524-97-1

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NUCC-390 (NUCC390)

货号: PC-20290Not For Human Use, Lab Use Only.

NUCC-390 (NUCC390) is a small molecule agonist of CXCR4, recapitulates the activity of CXCL12α.

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生物&药学活性

NUCC-390 (NUCC390) is a small molecule agonist of CXCR4, recapitulates the activity of CXCL12α.
NUCC-390 induces internalization of CXCR4 receptors.
NUCC-390 displays increased levels of phosphorylated ERK (pERK) in treated C8161 cells.
The effects of NUCC-390 could be completely inhibited by the selective CXCR4 antagonist AMD3100 (Cat#PC-42164).
NUCC-390 stimulates axonal growth and elongation via CXCR4 in cultured cerebellar granule neurons (CGNs), and in primary cultures of rat spinal cord motor neurons (SCMNs).
NUCC-390 promotes functional and anatomical recovery of the neuromuscular junction (NMJ) in mice.
NUCC-390 acts very similarly to the natural agonist ligand, the chemokine CXCL12α.

物理化学性质&存储条件

分子量	395.55
分子式	C23H33N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	piperidin-1-yl(1-propyl-5-((2-(pyridin-4-yl)ethyl)amino)-4,5,6,7-tetrahydro-1H-indazol-3-yl)methanone

参考文献

1. Negro S, et al. Cells. 2019 Sep 30;8(10):1183.

2. Mishra R, et al. Sci Rep. 2016 Jul 26:6:30155.

NUCC-390 (NUCC390)

生物&药学活性

物理化学性质&存储条件

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NUCC-390 (NUCC390)

生物&药学活性

物理化学性质&存储条件

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