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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-NUCC-390 dihydrochloride
NUCC-390 dihydrochloride

Chemical Structure : NUCC-390 dihydrochloride

CAS No.: 2749281-71-6

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NUCC-390 dihydrochloride (NUCC390 dihydrochloride)

货号: PC-20291Not For Human Use, Lab Use Only.

NUCC-390 dihydrochloride (NUCC390) is a small molecule agonist of CXCR4, recapitulates the activity of CXCL12α.

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5 mg ￥2780 In stock
10 mg ￥4580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NUCC-390 dihydrochloride (NUCC390) is a small molecule agonist of CXCR4, recapitulates the activity of CXCL12α.
NUCC-390 induces internalization of CXCR4 receptors.
NUCC-390 displays increased levels of phosphorylated ERK (pERK) in treated C8161 cells.
The effects of NUCC-390 could be completely inhibited by the selective CXCR4 antagonist AMD3100 (Cat#PC-42164).
NUCC-390 stimulates axonal growth and elongation via CXCR4 in cultured cerebellar granule neurons (CGNs), and in primary cultures of rat spinal cord motor neurons (SCMNs).
NUCC-390 promotes functional and anatomical recovery of the neuromuscular junction (NMJ) in mice.
NUCC-390 acts very similarly to the natural agonist ligand, the chemokine CXCL12α.

物理化学性质&存储条件

分子量 468.47
分子式 C23H35Cl2N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Methanone, 1-piperidinyl[4,5,6,7-tetrahydro-1-propyl-5-[[2-(4-pyridinyl)ethyl]amino]-1H-indazol-3-yl]-, hydrochloride (1:2)

参考文献

1. Negro S, et al. Cells. 2019 Sep 30;8(10):1183.

2. Mishra R, et al. Sci Rep. 2016 Jul 26:6:30155.

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