SCH-479833 | CXCR1/2 inhibitor | Probechem Biochemicals

Chemical Structure : SCH-479833

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SCH-479833 (SCH479833)

货号: PC-20802Not For Human Use, Lab Use Only.

SCH-479833 is a potent, specific and orally active CXCR1 and CXCR2 antagonist with Ki of 0.17 and 7 nM, respectively.

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生物&药学活性

SCH-479833 is a potent, specific and orally active CXCR1 and CXCR2 antagonist with Ki of 0.17 and 7 nM, respectively.
SCH-479833 inhibits microvessel density in human melanoma tumors, inhibits melanoma cell motility and invasion.
SCH-479833 inhibits A375SM cell proliferation and ERK1/2 signaling.
SCH-479833 (100 mg/kg, i.p.) inhibits proliferation and survival in human melanoma tumor mice model.

物理化学性质&存储条件

分子量	393.44
分子式	C22H23N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(N(C)C)C1=CC=CC(NC2=C(N[C@@H](C3=CC=CC=C3)CC)C(C2=O)=O)=C1O

参考文献

1. Singh S, et al. Clin Cancer Res. 2009 Apr 1;15(7):2380-6.

SCH-479833 (SCH479833)

生物&药学活性

物理化学性质&存储条件

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SCH-479833 (SCH479833)

生物&药学活性

物理化学性质&存储条件

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