UCUF-965 | CXCR4 modulator | Probechem Biochemicals

Chemical Structure : UCUF-965

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UCUF-965 (UCUF965)

货号: PC-21101Not For Human Use, Lab Use Only.

UCUF-965 (UCUF965) is a potent partial agonist and positive allosteric modulator of CXCR4 with EC50 of 0.02 uM, Emax=44% for CXCR4/CXCL12 signaling for β-arrestin-2 recruitment.

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生物&药学活性

UCUF-965 (UCUF965) is a potent partial agonist and positive allosteric modulator of CXCR4 with EC50 of 0.02 uM, Emax=44% for CXCR4/CXCL12 signaling for β-arrestin-2 recruitment.
UCUF-965 is a partial agonist of CXCR4-mediated β-arrestin activity.
UCUF-965 is a potential allosteric activator of CXCR4/CXCL12 signaling.
UCUF-965 activates endogenous CXCR4 cell signaling in CEM-CCRF lymphoblasts, induces migration with EC50 of 0.4 uM, 10 µM UCUF-965 induces CXCR4-mediated calcium flux in comparison to 10 nM CXCL12 in CEM-CCRF cells.
UCUF-965 modulates wound healing specific miRNA levels in diabetic murine fibroblasts.
UCUF- 965 (10 uM) enhances diabetic wound healing in mouse model of wound healing.

物理化学性质&存储条件

分子量	405.52
分子式	C22H23N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-ethoxyphenyl)-6-(4-(pyrrolidin-1-yl)phenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine

参考文献

1. Satyamaheshwar Peddibhotla, et al. Biochem Pharmacol. 2023 Aug 25;216:115764.

UCUF-965 (UCUF965)

生物&药学活性

物理化学性质&存储条件

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UCUF-965 (UCUF965)

生物&药学活性

物理化学性质&存储条件

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