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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-BMS-813160
BMS-813160

Chemical Structure : BMS-813160

CAS No.: 1286279-29-5

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BMS-813160 (BMS813160)

货号: PC-72668Not For Human Use, Lab Use Only.

BMS-813160 (BMS 813160) a potent and selective CCR2/5 dual antagonist with binding IC50 of 6.2/3.6 nM, respectively.

规格 价格 库存 数量
5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
50 mg ￥5880 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BMS-813160 (BMS 813160) a potent and selective CCR2/5 dual antagonist with binding IC50 of 6.2/3.6 nM, respectively.
BMS-813160 had excellent oral bioavailability and exhibited low clearance in dog and cyno.
BMS-813160 inhibited the migration of inflammatory monocytes and macrophages in the mouse thioglycollate-induced peritonitis model.

物理化学性质&存储条件

分子量 484.649
分子式 C25H40N8O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((1R,2S,5R)-2-((S)-3-((7-(tert-butyl)pyrazolo[1,5-a][1,3,5]triazin-4-yl)amino)-2-oxopyrrolidin-1-yl)-5-(tert-butylamino)cyclohexyl)acetamide

参考文献

1. Cherney RJ, et al. ACS Med Chem Lett. 2021 Oct 15;12(11):1753-1758.

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