BX471 | CCR1 antagonist | Probechem Biochemicals

Chemical Structure : BX471

CAS No.: 217645-70-0

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BX471 (BX-471, BX 471)

货号: PC-42889Not For Human Use, Lab Use Only.

BX471 is a potent, selective, non-peptide CCR1 antagonist with Ki of 1 nM for hCCR1, displays 100 times less affinity for rat CCR1.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

BX471 is a potent, selective, non-peptide CCR1 antagonist with Ki of 1 nM for hCCR1, displays 100 times less affinity for rat CCR1.
BX471 shows 10,000-fold selectivity for CCR1 compared with 28 GPCRs.
BX471 displays CCR1 ligands MIP-1α, RANTES, and MCP-3 with high affinity (Ki=1-5.5 nM), inhibits a number of CCR1-mediated effects including Ca(2+) mobilization, increase in extracellular acidification rate, CD11b expression.
BX471 effectively reduces disease in a rat experimental allergic encephalomyelitis model of multiple sclerosis.

物理化学性质&存储条件

分子量	434.8917
分子式	C21H24ClFN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 51 mg/mL
Chemical Name/SMILES	Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-

参考文献

1. Horuk R, et al. J Biol Chem. 2001 Feb 9;276(6):4199-204.

2. Anders HJ, et al. J Clin Invest. 2002 Jan;109(2):251-9.

3. Strasly M, et al. Blood. 2004 Jan 1;103(1):40-9.

4. Liang M, et al. J Biol Chem. 2000 Jun 23;275(25):19000-8.

BX471 (BX-471, BX 471)

生物&药学活性

物理化学性质&存储条件

参考文献

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BX471 (BX-471, BX 471)

生物&药学活性

物理化学性质&存储条件

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