PF-04136309 (INCB8761, PF-4136309) | CCR2 antagonist | Probechem Biochemicals

Chemical Structure : PF-04136309

CAS No.: 1341224-83-6

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PF-04136309 (INCB8761, PF-4136309, PF04136309, INCB-8761)

货号: PC-61557Not For Human Use, Lab Use Only.

PF-04136309 (INCB8761, PF-4136309) is a potent, selective, competitive, reversible full CCR2 antagonist with IC50 of 2-5 nM.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PF-04136309 (INCB8761, PF-4136309) is a potent, selective, competitive, reversible full CCR2 antagonist with IC50 of 2-5 nM.
PF-04136309 (INCB8761) depletes inflammatory monocytes and macrophages from the primary tumor and premetastatic liver resulting in enhanced antitumor immunity, decreased tumor growth, and reduced metastasis.

物理化学性质&存储条件

分子量	568.59
分子式	C29H31F3N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(2-(3-((4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide

参考文献

1. Sanford DE, et al. Clin Cancer Res. 2013 Jul 1;19(13):3404-15.

2. Nywening TM, et al. Lancet Oncol. 2016 May;17(5):651-62.

3. Xue CB, et al. ACS Med Chem Lett. 2011 Oct 5;2(12):913-8.

PF-04136309 (INCB8761, PF-4136309, PF04136309, INCB-8761)

生物&药学活性

物理化学性质&存储条件

参考文献

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PF-04136309 (INCB8761, PF-4136309, PF04136309, INCB-8761)

生物&药学活性

物理化学性质&存储条件

参考文献

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