AF-399 42016530 |CAS:618864-56-5 Probechem Biochemicals

Chemical Structure : AF-399 42016530

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AF-399 42016530 (AF-399/42016530)

货号: PC-61466Not For Human Use, Lab Use Only.

AF-399/42016530 is a potent CCR4 antagonist that blocked CCL22- and CCL17-mediated migration of human peripheral blood CD4+CD25+ Treg and Th2 cells ex-vivo and murine Tregs in-vivo.

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1 g		Get quote

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生物&药学活性

AF-399/42016530 is a potent CCR4 antagonist that blocked CCL22- and CCL17-mediated migration of human peripheral blood CD4+CD25+ Treg and Th2 cells ex-vivo and murine Tregs in-vivo.
AF-399/42016530 enhances DC-mediated human CD4(+) T cell proliferation in an in vitro immune response model and amplifies cellular and humoral immune responses in vivo in experimental models.
AF-399/42016530 induces antigen-specific CD8+ T cells and tumor immunity against self antigens in combination with vaccines.

物理化学性质&存储条件

分子量	531.619
分子式	C26H17N3O4S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(1-benzofuran-2-ylcarbonyl)-1-[5-(benzylsulfanyl)-1,3,4-thiadiazol-2-yl]-3-hydroxy-5-(2-thienyl)-1,5-dihydro-2H-pyrrol-2-one.

参考文献

1. Klein A, et al. Oncotarget. 2017 May 9;8(19):31079-31091.

2. Bayry J, et al. Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10221-6.

3. Pere H, et al. Blood. 2011 Nov 3;118(18):4853-62.

AF-399 42016530 (AF-399/42016530)

生物&药学活性

物理化学性质&存储条件

参考文献

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AF-399 42016530 (AF-399/42016530)

生物&药学活性

物理化学性质&存储条件

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