Ladarixin (DF 2156) | CXCR1/CXCR2 inhibitor | Probechem Biochemicals

Chemical Structure : Ladarixin

CAS No.: 849776-05-2

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Ladarixin (DF 2156, DF 2156A)

货号: PC-61474Not For Human Use, Lab Use Only.

Ladarixin (DF 2156) is an allosteric, noncompetitive dual CXCR1/2 inhibitor that inhibits human polymorphonuclear leukocyte (PMN) migration to CXCL8 in vitro with IC50 of 0.7 nM.

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10 mg	￥2980	In stock
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生物&药学活性

Ladarixin (DF 2156) is an allosteric, noncompetitive dual CXCR1/2 inhibitor that inhibits human polymorphonuclear leukocyte (PMN) migration to CXCL8 in vitro with IC50 of 0.7 nM.
Ladarixin (DF 2156) prevents PMN infiltration and tissue damage in several models of IR injury in vivo.
Ladarixin (DF 2156) abrogates motility and induces apoptosis in cultured cutaneous and uveal melanoma cells and xenografts.
Ladarixin (DF 2156) also prevents inflammation-mediated damage in MLD-STZ, prevents and reverses diabetes in NOD mice.

物理化学性质&存储条件

分子量	375.333
分子式	C11H12F3NO6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((2R)-1-Oxo-1-(methanesulfonamido)propan-2-yl)phenyl trifluoromethanesulfonate

参考文献

1. Garau A, et al. Eur Cytokine Netw. 2006 Mar;17(1):35-41.

2. Citro A, et al. Diabetes. 2015 Apr;64(4):1329-40.

3. Kemp DM, et al. Oncotarget. 2017 Feb 28;8(9):14428-14442.

4. Bertini R, et al. Br J Pharmacol. 2012 Jan;165(2):436-54.

Ladarixin (DF 2156, DF 2156A)

生物&药学活性

物理化学性质&存储条件

参考文献

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Ladarixin (DF 2156, DF 2156A)

生物&药学活性

物理化学性质&存储条件

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