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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-AMD3100
AMD3100

Chemical Structure : AMD3100

CAS No.: 110078-46-1

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AMD3100 (Plerixafor, JM-3100, AMD-3100, SID-791)

货号: PC-42164Not For Human Use, Lab Use Only.

Plerixafor (AMD3100) is a potent, selective CXCR4 inhibitor (IC50=44 nM) that inhibits the replication of various HIV-1 and HIV-2 strains in various cell lines with EC50 of 10ng/ml.

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10 mg ￥680 In stock
25 mg ￥980 In stock
50 mg ￥1580 In stock
100 mg ￥2380 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Plerixafor (AMD3100) is a potent, selective CXCR4 inhibitor (IC50=44 nM) that inhibits the replication of various HIV-1 and HIV-2 strains in various cell lines with EC50 of 10ng/ml.
Plerixafor (AMD3100) can produce mesenchymal stem cells and endothelial progenitor cells in mice in combination with VEGF.
Plerixafor (AMD3100) also is an allosteric agonist of CXCR7.

物理化学性质&存储条件

分子量 502.782
分子式 C28H54N8
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,4,8,11-Tetraazacyclotetradecane, 1,1'-[1,4-phenylenebis(methylene)]bis-

参考文献

1. Zabel BA, et al. J Immunol. 2009, 183(5), 3204-3211.

2. De Clercq E, et al. Antimicrob Agents Chemother. 1994 Apr;38(4):668-74.

3. Pitchford SC, et al. Cell Stem Cell. 2009 Jan 9;4(1):62-72.

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