CXCR2-IN-1 |CAS:1873376-49-8 Probechem Biochemicals

Chemical Structure : CXCR2-IN-1

CAS No.: 1873376-49-8

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CXCR2-IN-1

货号: PC-42300Not For Human Use, Lab Use Only.

CXCR2-IN-1 is a potent, CNS penetrant CXCR2 antagonist with pIC50 of 9.3.

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5 mg	￥880	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

CXCR2-IN-1 is a potent, CNS penetrant CXCR2 antagonist with pIC50 of 9.3.
CXCR2-IN-1 shows neutrophil chemotaxis inhibition with pIC50 of 7.6.
CXCR2-IN-1 has developability profiles (CYP inhibition pIC<5.0, and hERG binding affinity pIC<4.0).
CXCR2-IN-1 exhibits favorable PK profile, reasonable CNS penetration, and good developability potential; orally bioavailable.

物理化学性质&存储条件

分子量	476.3492032
分子式	C19H20Cl2FN3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥5.4 mg/mL (Need ultrasonic and warming)
Chemical Name/SMILES	Urea, N-(2-chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]-

参考文献

1. Xu H, et al. ACS Med Chem Lett. 2016 Feb 8;7(4):397-402.

CXCR2-IN-1

生物&药学活性

物理化学性质&存储条件

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CXCR2-IN-1

生物&药学活性

物理化学性质&存储条件

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