INCB3344 | CCR2 antagonist | Probechem Biochemicals

Chemical Structure : INCB3344

CAS No.: 1262238-11-8

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INCB3344 (INCB 3344, INCB-3344)

货号: PC-45838Not For Human Use, Lab Use Only.

INCB3344 (INCB 3344) is a potent, selective and orally bioavailable CCR2 antagonist with IC50 of 5.1 nM and 9.5 nM for hCCR2 and mCCR2, respectively, in MCP-1 binding assays.

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3680	In stock
50 mg	￥5680	In stock
100 mg		Get quote

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生物&药学活性

INCB3344 (INCB 3344) is a potent, selective and orally bioavailable CCR2 antagonist with IC50 of 5.1 nM and 9.5 nM for hCCR2 and mCCR2, respectively, in MCP-1 binding assays.
INCB3344 show no significant activity for murine CCR1 and murine CCR5 (IC50>1 uM), and a panel of >50 ion channels, transporters, chemokine receptors and other selected GPCRs.
INCB3344 inhibits macrophage influx in a mouse model of delayed-type hypersensitivity, significantly reduces disease in models of multiple sclerosis, and inflammatory arthritis.

物理化学性质&存储条件

分子量	577.592
分子式	C29H34F3N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-[2-[[(3R,4R)-1-[trans-4-(1,3-benzodioxol-5-yl)-4-hydroxycyclohexyl]-4-ethoxy-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-, rel-

参考文献

1. Brodmerkel CM, et al. J Immunol. 2005 Oct 15;175(8):5370-8.

2. Xue CB, et al. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7473-8.

3. Zweemer AJ, et al. Mol Pharmacol. 2013 Oct;84(4):551-61.

INCB3344 (INCB 3344, INCB-3344)

生物&药学活性

物理化学性质&存储条件

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INCB3344 (INCB 3344, INCB-3344)

生物&药学活性

物理化学性质&存储条件

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