MK-0812 succinate |CAS:851916-42-2 Probechem Biochemicals

Chemical Structure : MK-0812 succinate

CAS No.: 851916-42-2

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MK-0812 succinate (MK 0812 Succinate;MK0812 Succinate)

货号: PC-45834Not For Human Use, Lab Use Only.

A potent CCR2 specific antagonist that blocks MCP-1 mediated response with an IC50 of 3.2 nM.

规格	价格	库存
10 mg	￥2240	In stock
50 mg	￥7840	In stock
100 mg	￥12400	In stock

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生物&药学活性

A potent CCR2 specific antagonist that blocks MCP-1 mediated response with an IC50 of 3.2 nM; inhibits 125I-MCP-1 binding on isolated monocytes with IC50 of 4.5 nM; reduces macrophage accumulation in adipose tissue in ob/ob mice.

Multiple Sclerosis

Phase 2 Discontinued

物理化学性质&存储条件

分子量	587.6283
分子式	C28H40F3N3O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	D-erythro-Pentitol, 1,5-anhydro-2,3-dideoxy-3-[[(1R,3S)-3-[[7,8-dihydro-3-(trifluoromethyl)-1,6-naphthyridin-6(5H)-yl]carbonyl]-3-(1-methylethyl)cyclopentyl]amino]-4-O-methyl-, butanedioate (1:1)

参考文献

1. Wisniewski T, et al. J Immunol Methods. 2010 Jan 31;352(1-2):101-10.

2. O'Brien PD, et al. Diabetes Obes Metab. 2017 Mar 23. doi: 10.1111/dom.12950.

3. Min SH, et al. Biochem Biophys Res Commun. 2010 Jan 1;391(1):1080-6.

MK-0812 succinate (MK 0812 Succinate;MK0812 Succinate)

生物&药学活性

物理化学性质&存储条件

参考文献

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MK-0812 succinate (MK 0812 Succinate;MK0812 Succinate)

生物&药学活性

物理化学性质&存储条件

参考文献

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