Vicriviroc maleate | CCR5 antagonist | Probechem Biochemicals

Chemical Structure : Vicriviroc maleate

CAS No.: 599179-03-0

加入收藏

Vicriviroc maleate (SCH417690, SCH-D, MK-7690)

货号: PC-45199Not For Human Use, Lab Use Only.

Vicriviroc maleate (SCH417690) is a potent, highly selective, and orally bioavailable CCR5 antagonist with Ki of 2.5 nM.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3680	In stock
50 mg	￥5580	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Vicriviroc maleate (SCH417690) is a potent, highly selective, and orally bioavailable CCR5 antagonist with Ki of 2.5 nM.
Vicriviroc maleate (SCH417690) display no affinity for muscarinic receptors (Ki>10 uM).
Vicriviroc maleate (SCH417690) inhibits HIV-1 entry into U-80 cells with IC50 of 0.8 nM, inhibits HIV-1 clinical isolates in PBMC with IC90 of 1-10 nM.
Vicriviroc maleate (SCH417690) exhibits excellent receptor selectivity and oral bioavailability in rats and monkeys.

物理化学性质&存储条件

分子量	649.701
分子式	C32H42F3N5O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Piperidine, 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-[(3S)-4-[(1R)-2-methoxy-1-[4-(trifluoromethyl)phenyl]ethyl]-3-methyl-1-piperazinyl]-4-methyl-, (2Z)-2-butenedioate (1:1)

参考文献

1. Tagat JR, et al. J Med Chem. 2004 May 6;47(10):2405-8.

2. Marozsan AJ, et al. Virology. 2005 Jul 20;338(1):182-99.

3. Strizki JM, et al. Antimicrob Agents Chemother. 2005 Dec;49(12):4911-9.

Vicriviroc maleate (SCH417690, SCH-D, MK-7690)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Vicriviroc maleate (SCH417690, SCH-D, MK-7690)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.