MR120 (CCR6 antagonist 1b) | CCR6 inhibitor | Probechem Biochemicals

Chemical Structure : MR120

CAS No.: 588674-64-0

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MR120 (MR-120, CCR6 antagonist 1b)

货号: PC-49306Not For Human Use, Lab Use Only.

MR120 (CCR6 antagonist 1b) is a potent, selective CCR6 antagonist, disrupts the CCL20-induced chemotaxis of CCR6+CD4+ T cells.

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25 mg	￥1580	In stock
50 mg	￥2580	In stock
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生物&药学活性

MR120 (CCR6 antagonist 1b) is a potent, selective CCR6 antagonist, disrupts the CCL20-induced chemotaxis of CCR6+CD4+ T cells.

MR120 (50 μM, 3 h) blocks the CCL20-induced CD4+ T cell migration.

MR120 (30 nM-300 μM) inhibits miniGi recruitment to CCR6 induced by CCL20, and β-arrestin-1 recruitment to CCR6 and CCR5 by CCL20 and CCL5 (5 nM), respectively.

MR120 (1 mg/kg, s.c., twice daily for 3 days) alleviates TNBS-induced inflammatory responses in mice, shows anti-inflammatory effects

in Zymosan-induced peritonitis mice.

MR120 is a first-in-class inhibitor for IBDs targeting the CCL20/CCR6 axis.

物理化学性质&存储条件

分子量	319.283
分子式	C17H12F3NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-methyl-N-(4-(trifluoromethyl)phenyl)benzofuran-2-carboxamide

参考文献

1. Maria Grazia Martina, et al. Eur J Med Chem. 2022 Aug 29;243:114703.
2. Allodi M, et al. Eur J Pharmacol. 2023 Feb 23:175613.

MR120 (MR-120, CCR6 antagonist 1b)

生物&药学活性

物理化学性质&存储条件

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MR120 (MR-120, CCR6 antagonist 1b)

生物&药学活性

物理化学性质&存储条件

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