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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-ACT-672125
ACT-672125

Chemical Structure : ACT-672125

CAS No.: 1449367-94-5

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ACT-672125 (ACT672125)

货号: PC-49264Not For Human Use, Lab Use Only.

ACT-672125 (ACT672125) is a potent, selective CXCR3 antagonist with IC50 of 239 nM in human blood.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ACT-672125 (ACT672125) is a potent, selective CXCR3 antagonist with IC50 of 239 nM in human blood.
    ACT-672125 showed good physicochemical properties and safety profile.
    ACT-672125 inhibited the recruitment of CXCR3 expressing T cells into the inflamed lung in a dose-dependent manner in proof-of-mechanism model of lung inflammation.

    物理化学性质&存储条件

    分子量 586.598
    分子式 C25H25F3N10O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-2-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-1-(2-methyl-4-(4-(5-(5-methyl-1,2,4-oxadiazol-3-yl)-1H-benzo[d]imidazol-2-yl)-2-(trifluoromethyl)thiazol-5-yl)piperazin-1-yl)ethan-1-one

    参考文献

    1. Eva Caroff, et al. J Med Chem. 2022 Aug 15. doi: 10.1021/acs.jmedchem.2c00676.

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