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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-RPT193
RPT193

Chemical Structure : RPT193

CAS No.: 2366152-15-8

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RPT193 (Zelnecirnon, RPT-193)

货号: PC-49464Not For Human Use, Lab Use Only.

RPT193 (RPT-193) is a highly potent, selective and orally active CCR4 antagonist, inhibits CCL22- induces human Th2 chemotaxis with IC50 of 370 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RPT193 (Zelnecirnon, RPT-193) is a highly potent, selective and orally active CCR4 antagonist, inhibits CCL22- induces human Th2 chemotaxis with IC50 of 370 nM.
RPT193 (Zelnecirnon) shows greater potency against Th2 chemotaxis than previous CCR4 antagonists (AZD-2098, GSK2239633).
RPT193 (Zelnecirnon) (100 mg/kg, oral) reduces skin inflammation in an acute OVA-induced atopic dermatitis model, significantly reduces Th2 cell migration into inflamed skin.

物理化学性质&存储条件

分子量 566.95
分子式 C27H34Cl3N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

trans-3-[(3R)-3-[1-[5-Chloro-4-[[(1R)-1-(2,4-dichlorophenyl)ethyl]amino]-6-methyl-2-pyrimidinyl]-3-azetidinyl]-1-piperidinyl]-1-methylcyclobutanecarboxylic acid

参考文献

1. Robert Bissonnette, et al. Allergy. 2024 Apr;79(4):924-936.

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