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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-LN6023
LN6023

Chemical Structure : LN6023

CAS No.: 3035427-42-7

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LN6023 (LN-6023)

货号: PC-49368Not For Human Use, Lab Use Only.

LN6023 (LN-6023) is a potent, selective and first-in-class agonist of the atypical chemokine receptor 3 (ACKR3, CXCR7) with β-arrestin EC50 of 3.5 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    LN6023 (LN-6023) is a potent, selective and first-in-class agonist of the atypical chemokine receptor 3 (ACKR3, CXCR7) with β-arrestin EC50 of 3.5 uM.
    LN6023 effectively reduced P-selectin expression by up to 97% in a platelet degranulation assay, showed potential for the treatment of platelet-mediated thrombosis.

    物理化学性质&存储条件

    分子量 420.576
    分子式 C20H32N6O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(tert-butyl)-1-(3-((7-ethyl-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)amino)propyl)piperidine-4-carboxamide

    参考文献

    1. Alp Bayrak, et al. J Med Chem. 2022 Oct 13;65(19):13365-13384.

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