RIST 4721 (Vimnerixin, AZD 4721) | CXCR2 inhibitor | Probechem Biochemicals

Chemical Structure : RIST4721

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RIST4721 (Vimnerixin, AZD4721)

货号: PC-49866Not For Human Use, Lab Use Only.

RIST 4721 (Vimnerixin, AZD 4721) is a potent, specific and orally active antagonist of CXCR2, potently inhibits neutrophil chemotaxis with IC50 of 17 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

RIST 4721 (Vimnerixin, AZD 4721) is a potent, specific and orally active antagonist of CXCR2, potently inhibits neutrophil chemotaxis with IC50 of 17 nM.
RIST 4721 (10 nM and 100 nM) potently inhibits keratinocyte chemokine (KC) mediated chemotaxis in a dose-dependent manner.
RIST4721 (1 μM) completely abrogates any additional chemotaxis stimulated with KC, indicating the complete inhibition of CXCR2 activities.
RIST4721 does not change FBS-mediated responses, indicating chemotaxis inhibition is CXCR2-specific.
RIST4721 does not alter the proliferation rates of mitotically active neutrophil progenitors.
RIST4721-treated neutrophils exhibits robust phagocytosis and reactive oxygen species production, confirming drug specificity to chemotaxis inhibition.

物理化学性质&存储条件

分子量	472.55
分子式	C19H25FN4O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)-2-((4-fluorobenzyl)thio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide

参考文献

1. Szymczak K, et al. Biomedicines. 2023 Feb 7;11(2):479.

2. Bissonnette R, et al. Dermatol Ther (Heidelb). 2021 Dec;11(6):2179-2193.