| Cat. No. |
Product Name |
Information |
| PC-26500 |
WEHI-092
USP9X inhibitor
|
WEHI-092 is a potent and selective inhibitor of USP9X with IC50 of 254 nM, directly binds to USP9X catalytic domain with SPR KD of 1 uM, does not inhibit USP24 and other DUBs. |
| PC-26479 |
P6620
USP7 inhibitor
|
P6620 is a specific small molecule inhibitor USP7, effectively inhibits the USP7/LRRC41 axis to suppress HCC malignancy. |
| PC-26236 |
USP11 inhibitor 26
USP11 inhibitor
|
USP11 inhibitor 26 (USP11-IN-1) is a selective inhibitor of USP11 with IC50 of 10.9 uM, shows 1.7- and >100-fold selective over USP4 and USP15. |
| PC-26235 |
USP11 inhibitor 7
USP11 inhibitor
|
USP11 inhibitor 7 (USP11-IN-2) is a selective inhibitor of USP11 with IC50 of 2.6 uM, shows >30- and 100-fold selective over USP4 and USP15. |
| PC-26201 |
WWQ-03-012
DESI2 inhibitor
|
WWQ-03-012 is a potent, specific and covalent inhibitor of JAK2‐V617F complex component DESI2 with IC50 of 47.3 nM, selectively degrades mutant JAK2. |
| PC-25571 |
OAT-4828 dihydrochloride
USP7 inhibitor
|
OAT-4828 dihydrochloride is a potent, and selective USP7 inhibitor with IC50 of 22 nM in enzymatic assay and 33 nM in reporter assay (Ub-CHOP reporter system). |
| PC-25550 |
USP19-IN-1
USP19 inhibitor
|
USP19-IN-1 (Example 124) is a potent, selective USP19 inhibitor with IC50 of <0.5 uM, high selective against a panel of 24 USPs and 19 other DUBs. |
| PC-25142 |
USP10 inhibitor LY-2
USP10 inhibitor
|
USP10 inhibitor LY-2 is a potent ubiquitin-specific protease 10 (USP10) inhibitor with SPR binding KD of 365 nM and IC50 of 10.87 uM. |
| PC-24885 |
Hyperoside
USP18 inhibitor
|
Hyperoside is a naturally occurring flavonol glycoside with anti-colitis and anticancer potential, also is a USP18 inhibitor that directly targets the USP18 IBB1 domain (BLI KD=7.04 uM), hyperoside inhibits PRRSV proliferation via the TLR4/NF-kappaB and p62-Nrf2-Keap1 signaling pathways. |
| PC-24793 |
STIRUR 41
USP7 inhibitor
|
STIRUR 41 (STIRUR-41, STIR UR 41) is a small molecule USP-7 inhibitor with IC50 of 2.77 uM in HTLA-230 cells, STIRUR 41 (5-10 uM) STIRUR 41 induces a remarkable decrease in USP-7 protein levels in HTLA-230 cells. |
| PC-24536 |
NK036
USP30 inhibitor
|
NK036 is a solubility-enhanced derivative of USP30 inhibitor Compound 39 (CMPD-39), has IC50 of 7.4 nM and 4.1 nM for human USP30 (construct 1 (c1) and USP ch3, respectively. |
| PC-24507 |
K-552
USP47 inhibitor
|
K-552 is a specific small molecule inhibitor of USP47 with Kd of 12.3 uM (cUSP47CD), shows more specific interactions with cUSP47CD than hUSP7CD. |
