USP7 inhibitor ALM4| CAS 2196243-57-7 Probechem Biochemicals

Chemical Structure : USP7 inhibitor ALM4

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USP7 inhibitor ALM4 (AD-04, (R)-USP-IN-4, USP7 inhibitor 4)

货号: PC-60003Not For Human Use, Lab Use Only.

USP7 inhibitor ALM4 (AD-04) is a highly potent, selective, allosteric USP7 inhibitor with IC50 of 6 nM in FP assays, SPR Kd of 2 nM.

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生物&药学活性

USP7 inhibitor ALM4 (AD-04) is a highly potent, selective, allosteric USP7 inhibitor with IC50 of 6 nM in FP assays, SPR Kd of 2 nM.
AD-04 also shows high potency in an alternative assay using the Ub-Rh110 substrate (IC50=1.5 nM).
AD-04 displays high selectivuty (>38-fold) against other DUBs, proteases and kinases.
AD-04 demonstrates highly potent target engagement in cells (EC50=49 nM), with no off-target activity against USP47, causes nongenotoxic stabilization of p53 and decreased levels of MDM2 in HCT116 cells.

物理化学性质&存储条件

分子量	514.63
分子式	C29H34N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-(4-(aminomethyl)phenyl)-6-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-2-methyl-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

参考文献

1. Gavory G, et al. Nat Chem Biol. 2018 Feb;14(2):118-125.
2. Anamarija Jurisic, et al. Clin Transl Med. 2024 Apr;14(4):e1648.

USP7 inhibitor ALM4 (AD-04, (R)-USP-IN-4, USP7 inhibitor 4)

生物&药学活性

物理化学性质&存储条件

参考文献

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USP7 inhibitor ALM4 (AD-04, (R)-USP-IN-4, USP7 inhibitor 4)

生物&药学活性

物理化学性质&存储条件

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