SJB3-019A | USP1 inhibitor | Probechem Biochemicals

Chemical Structure : SJB3-019A

CAS No.: 2070015-29-9

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SJB3-019A (USP1 inhibitor SJB3-019A)

货号: PC-46007Not For Human Use, Lab Use Only.

SJB3-019A is a potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1 nM, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

SJB3-019A is a potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1 nM, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells.
SJB3-019A also increases the levels of Ub-FANCD2 and Ub-PCNA, and decreases the HR activity.
SJB3-019A triggers apoptosis in multiple myeloma cells via activation of caspase-3/8/9, degrades USP1 and downstream inhibitor of DNA-binding proteins as well as inhibits DNA repair via blockade of Fanconi anemia pathway and homologous recombination.
SJB3-019A downregulates multiple myeloma stem cell Notch-1, Notch-2, SOX-4, and SOX-2, and induces generation of more mature and differentiated plasma cells.

物理化学性质&存储条件

分子量	276.2463
分子式	C16H8N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(pyridin-3-yl)naphtho[2,3-d]oxazole-4,9-dione

参考文献

1. Mistry H, et al. Mol Cancer Ther. 2013 Dec;12(12):2651-62.

2. Das DS, et al. Clin Cancer Res. 2017 Mar 7. doi: 10.1158/1078-0432.CCR-16-2692.

SJB3-019A (USP1 inhibitor SJB3-019A)

生物&药学活性

物理化学性质&存储条件

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SJB3-019A (USP1 inhibitor SJB3-019A)

生物&药学活性

物理化学性质&存储条件

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