USP8-IN-22c |CAS:924296-17-3 Probechem Biochemicals

Chemical Structure : USP8-IN-22c

CAS No.: 924296-17-3

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USP8-IN-22c (compounds 22c)

货号: PC-45857Not For Human Use, Lab Use Only.

USP8-IN-22c is a potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.56 uM.

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5 mg	￥2380	In stock
10 mg	￥3880	In stock
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生物&药学活性

USP8-IN-22c is a potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.56 uM.
USP8-IN-22c shows no inhibitory activity for USP7, USP5, SENP1, Uch-L3, and caspase 3 (IC50>100 uM), and displays partial activity against Uch-L3.
USP8-IN-22c inhibits the viability of HCT116 colon and PC-3 prostate cancer cell lines with IC50 values in the 0.5-1.5 uM range.

物理化学性质&存储条件

分子量	287.2756
分子式	C16H9N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 20.1 mg/mL
Chemical Name/SMILES	9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-[(2-propen-1-yloxy)imino]-

参考文献

1. Colombo M, et al. ChemMedChem. 2010 Apr 6;5(4):552-8.

USP8-IN-22c (compounds 22c)

生物&药学活性

物理化学性质&存储条件

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USP8-IN-22c (compounds 22c)

生物&药学活性

物理化学性质&存储条件

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