NSC632839 |CAS:157654-67-6 Probechem Biochemicals

Chemical Structure : NSC632839

CAS No.: 157654-67-6

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NSC632839 (NSC-632839;NSC 632839;Ubiquitin Isopeptidase-IN-F6)

货号: PC-42231Not For Human Use, Lab Use Only.

NSC632839 is a small molecule inhibitor of ubiquitin-proteasome system by inhibiting the ubiquitin isopeptidases, inhibits USP2, USP7, and SENP2 with EC50 values of 45 μM, 37 μM, and 9.8 μM, respectively.

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25 mg	￥1380	In stock
50 mg	￥2180	In stock
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生物&药学活性

NSC632839 is a small molecule inhibitor of ubiquitin-proteasome system by inhibiting the ubiquitin isopeptidases, inhibits USP2, USP7, and SENP2 with EC50 values of 45 μM, 37 μM, and 9.8 μM, respectively.
NSC632839 induces a unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with up-regulation of the BH3-only protein Noxa, stabilization of the IAP antagonist Smac, but also the involvement of the death receptor pathway.

物理化学性质&存储条件

分子量	339.8585
分子式	C21H22ClNO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 6.2 mg/mL (Need warming)
Chemical Name/SMILES	4-Piperidinone, 3,5-bis[(4-methylphenyl)methylene]-, hydrochloride (1:1)

参考文献

1. Aleo E, et al. Cancer Res. 2006 Sep 15;66(18):9235-44.

2. Nicholson B, et al. Protein Sci. 2008 Jun;17(6):1035-43.

NSC632839 (NSC-632839;NSC 632839;Ubiquitin Isopeptidase-IN-F6)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

NSC632839 (NSC-632839;NSC 632839;Ubiquitin Isopeptidase-IN-F6)

生物&药学活性

物理化学性质&存储条件

参考文献

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