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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-LDN-57444
LDN-57444

Chemical Structure : LDN-57444

CAS No.: 668467-91-2

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LDN-57444 (LDN57444)

货号: PC-45498Not For Human Use, Lab Use Only.

LDN57444 is a potent, reversible, competitive, active site-directed UCHL1 inhibitor with IC50 of 0.88 uM.

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5 mg ￥480 In stock
10 mg ￥780 In stock
25 mg ￥1380 In stock
50 mg ￥2180 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LDN57444 is a potent, reversible, competitive, active site-directed UCHL1 inhibitor with IC50 of 0.88 uM.
LDN57444 shows weak inhibition on Uch-L3 (IC50> 20 uM).
LDN57444 causes cell death through the apoptosis pathway by decreasing the activity of ubiquitin proteasome system and increasing the levels of highly ubiquitinated proteins, both of which can activate UPR.

物理化学性质&存储条件

分子量 397.6398
分子式 C17H11Cl3N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime)

参考文献

1. Gong B, et al. Cell. 2006 Aug 25;126(4):775-88.

2. Xie M, et al. J Alzheimers Dis. 2016;49(2):353-63.

3. Tan YY, et al. Mol Cell Biochem. 2008 Nov;318(1-2):109-15.

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