| Cat. No. |
Product Name |
Information |
| PC-49689 |
I-138
UPS1 inhibitor
|
I-138 (I 138) is a potent, specific small molecule USP1-UAF1 inhibitor with IC50 of 4.1 nM, binds to USP1-UAF1 at an allosteric pocket synergistically with ubiquitin. |
| PC-49626 |
8RK64
UCHL1 inhibitor
|
8RK64 is a covalent small molecule inhibitor of ubiquitin carboxy-terminal hydrolase L1 (UCHL1, PGP9.5, PARK5) enzyme with IC50 of 0.32 uM, >80-fold selectivity over UCHL3 and UCHL5. |
| PC-49546 |
Usp22i-S02
USP22 inhibitor
|
Usp22i-S02 (Usp22 inhibitor S02) is a specific small-molecule inhibitor of the Foxp3-specific deubiquitinase USP22, down-regulates Foxp3 expression in Treg cells in a Usp22- but not Usp21-dependent manner. |
| PC-49371 |
GK13S
UCHL1 inhibitor
|
GK13S is a highly potent, specific and covalent inhibitor of deubiquitinase UCHL1 with IC50 of 87 nM, displays exquisite specificity for UCHL1 over the other UCH family members (IC50>10 uM). |
| PC-49051 |
DC-U4106
USP8 inhibitor
|
DC-U4106 is a potent, selective small molecule inhibitor of Ubiquitin-specific protease 8 (USP8) with binding KD value of 4.7 uM, DC-U4106 is selective over USP2 and USP7. |
| PC-38772 |
C673-0105
USP10 inhibitor
|
C673-0105 is a selective, small molecule inhibitor of USP10, inhibits USP10 comparably to HBX19818 (IC50=10 uM), with no inhibition against USP7 (IC50>100 uM). |
| PC-38771 |
C598-0556
USP10 inhibitor
|
C598-0556 is a selective, small molecule inhibitor of USP10, inhibits USP10 comparably to HBX19818 (IC50=10 uM), with no inhibition against USP7 (IC50>100 uM). |
| PC-38692 |
FT709
USP9X inhibitor
|
FT709 is a potent, highly selective USP9X inhibitor with IC50 of 82 nM in biochemical assays, reduces CEP55 expression in BxPC3 pancreatic cancer cells with IC50 of 131 nM. |
| PC-38585 |
USP10 inhibitor Wu-5
USP10 inhibitor
|
USP10 inhibitor Wu-5 (Wu-5) is a novel small molecule USP10 inhibitor inducing the degradation of FLT3-mutated protein, directly interacts and inactivates USP10, the deubiquitinase for FLT3-ITD in vitro (IC50=8.3 uM) and in FLT3-ITD-positive AML cells. |
| PC-73355 |
Subquinocin
CYLD inhibitor
|
Subquinocin is a small molecule inhibitor of DUB activity of CYLD with IC50 of 30 uM, enhances NF-κB activation by inhibiting CYLD. |
| PC-73354 |
USP inhibitor 2
USP4 inhibitor
|
USP inhibitor 2 is a broad DUB inhibitor with IC50 of 0.04 and 0.21 uM for USP4 and USP11, also inhibits USP10/16/15/19 with submicromolar potency, forms a covalent adduct with USP11. USP inhibitor 2 does not inhibit USP5 (IC50>100 uM). |
| PC-73353 |
USP inhibitor 1
USP33 inhibitor, USP4 inhibitor
|
USP inhibitor 1 is an irreversible USP inhibitor with submicromolar IC50 of USP4 and its phylogenetic relative USP11, also functionally inhibits USP33, leading to CP110 instability and synergy with ATR inhibition. |
