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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-P22077
P22077

Chemical Structure : P22077

CAS No.: 1247819-59-5

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P22077 (P 22077)

货号: PC-21881Not For Human Use, Lab Use Only.

P22077 is a selective cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor with IC50 of 8.01 uM, also inhibits USP47 with IC50 of 8.47 uM.

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10 mg ￥580 In stock
25 mg ￥980 In stock
50 mg ￥1480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

P22077 is a selective cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor with IC50 of 8.01 uM, also inhibits USP47 with IC50 of 8.47 uM.
P22077 oes not significantly affect other DUBs (USP1, 4, 8, 10, 16, 19, 22, 24, 28, 48, VCIP135, OTUD5, BAP1, ATXN3, YOD1, and UCH-L5) at 25 uM.

物理化学性质&存储条件

分子量 315.31
分子式 C12H7F2NO3S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(5-((2,4-Difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone

参考文献

1. Altun M, et al. Chem Biol. 2011 Nov 23;18(11):1401-12.

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