YCH2823 | USP7 inhibitor | Probechem Biochemicals

Chemical Structure : YCH2823

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YCH2823 (YCH 2823)

货号: PC-21796Not For Human Use, Lab Use Only.

YCH2823 is a potent, selective USP7 inhibitor with IC50 of 49.6 nM, ITC Kd of 117 nM.

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生物&药学活性

YCH2823 is a potent, selective USP7 inhibitor with IC50 of 49.6 nM, ITC Kd of 117 nM.
YCH2823 demonstrates a dose-dependent inhibition of cell proliferation in MM.1S cells with IC50 of 102.4 nM.
YCH2823 shows significantly lower IC50 value comapred to FT671 (Cat# PC-60088) against in both TP53 wild-type and -mutant cells.
YCH2823 significantly inhibits the viability of CHP-212 and NCI-H526 cells, with IC50 values of 8.43 nM and 40.64 nM, respectively.
YCH2823 induces cell cycle arrest, apoptosis, and expression of BCL6.
YCH2823 is synergistically with mTOR inhibitors against CHP-212 and IMR32 cells.

物理化学性质&存储条件

分子量	500.60
分子式	C29H32N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-7-(4-methoxyphenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

参考文献

1. Yong-Jun Cheng, et al. Biochem Pharmacol. 2024 Feb 20:116071.

YCH2823 (YCH 2823)

生物&药学活性

物理化学性质&存储条件

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YCH2823 (YCH 2823)

生物&药学活性

物理化学性质&存储条件

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