LN5P45 | OTUB2 inhibitor | Probechem Biochemicals

Chemical Structure : LN5P45

CAS No.: 2307750-78-1

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LN5P45 (OTUB2 inhibitor)

货号: PC-21098Not For Human Use, Lab Use Only.

LN5P45 is a selective, covalent, irreversible inhibitor of ubiquitin thioesterase OTUB2 with IC50 of 2.3 uM, strongly induces monoubiquitination of OTUB2 on Lys31.

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生物&药学活性

LN5P45 is a selective, covalent, irreversible inhibitor of ubiquitin thioesterase OTUB2 with IC50 of 2.3 uM, strongly induces monoubiquitination of OTUB2 on Lys31.
LN5P45 is about 20-fold more potent toward OTUB2 over OTUD3 (IC50=56 uM).
LN5P45 also shows no activity against the closest family members OTUB1, OTUD1, OTUD2, OTUD3, OTUD6B, and Cezanne, and DUBs UCHL1 and USP16 (IC50>100 uM).
LN5P45 (10 uM) displays clear inhibition of GFP-OTUB2 in HEK293T cells, LN5P45 engages endogenous OTUB2 and is selective for OTUB2 over other ubiquitin machinery components.

物理化学性质&存储条件

分子量	266.73
分子式	C13H15ClN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,2S)-N'-(2-chloroacetyl)-2-(m-tolyl)cyclopropane-1-carbohydrazide

参考文献

1. Jin Gan, et al. ACS Chem Biol. 2023 Aug 29.

LN5P45 (OTUB2 inhibitor)

生物&药学活性

物理化学性质&存储条件

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