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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-IMP-2373
IMP-2373

Chemical Structure : IMP-2373

CAS No.:

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IMP-2373 (IMP2373)

货号: PC-21498Not For Human Use, Lab Use Only.

IMP-2373 is a highly targeted cyanopyrrolidine (CNPy) probe for pan-DUB to monitor DUB activity in physiologically relevant live cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    IMP-2373 is a highly targeted cyanopyrrolidine (CNPy) probe for pan-DUB to monitor DUB activity in physiologically relevant live cells.
    IMP-2373 is a potent broad-spectrum DUB enzyme inhibitor with minimal off-target cytotoxicity.
    IMP-2373 act as a competitive probe for in-cell target engagement by selective DUB inhibitors.
    IMP-2373 is a powerful and useful application of activity-based probe (ABP) in drug discovery and development.

    物理化学性质&存储条件

    分子量 360.42
    分子式 C21H20N4O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(1-cyanopyrrolidine-3-carbonyl)-N-(4-ethynylbenzyl)-1-methyl-1H-pyrrole-2-carboxamide

    参考文献

    1. Daniel Conole, et al. Angew Chem Int Ed Engl. 2023 Nov 20;62(47):e202311190.

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